|Course Name||Course Description||No. of Credits||Code|
|Bioorganic Chemistry and Drug Metabolism||Prerequisites:Pharmaceutical Organic Chemistry
Bioorganic chemistry and drug metabolism is a three credit course offered in first semester of MS pharmaceutical chemistry. The course focuses on the study of organic chemistry of biological molecules with special emphasis on chemical principles, an extension of basic organic chemistry as applied to the mechanisms by which biologically relevant molecules react and exert their effects.
This course is focusing on drug metabolism or drug biotransformation and enzyme- catalyzed changes in drug structure. Enzymology of drug metabolism reactions including the molecular mechanisms involved. Factors that modulate drug metabolism, and induction and inhibition and external and internal factors are considered in view of the widespread use of poly-pharmacy that the student should not only be aware of potential drug-drug interactions but also be able to rationalize and explain why combination drug therapy interactions occur. The importance of pharmacokinetics in drug action is highlighted. The students gain knowledge in changes in both pharmacological and toxicological responses due to drug biotransformation with an important consideration in drug therapy and pro-drug design. Learning is facilitated through interactive lecture sessions, self-directed learning (assignments, problem based learning, seminar) and course examinations.
|Theory 3 + Practical 0 = 3||PBDM 611|
|Advanced Pharmaceutical Organic Chemistry||Prerequisites: Pharmaceutical Analytical Chemistry
The instrumental analytical course is a four credit course offered in the first semester of first year of MS pharmaceutical chemistry curriculum. This course aim to illustrate the theory and practice of quantitative analysis at the advanced level. This course covers the fundamentals of instrumental methods of analysis, emphasizing spectroscopic, chromatographic techniques. This course provides information about the different instrumental techniques employed in qualitative and quantitative determination of drug substances with special reference to quality control and quality assurance. Instrumental/pharmaceutical analysis is vital for successful drug development. It is used to determine a drug’s structure, level of active ingredient and identify contaminants. Pharmaceutical analysts use range of techniques to examine the constituents of various samples throughout the drug development process. These samples include raw materials used in manufacturing and body fluids collected during drug trials. As an analyst the student must be familiar with the principles of modern instrumental analytical techniques, approaches and pharmacology. Regulation demands the work under a strict quality assurance and quality control. Learning is facilitated through interactive lecture sessions, laboratory sessions, self-directed learning (assignments, problem based learning, seminar), laboratory practical experiments and course examinations.
|Theory 2 + Practical 2 = 4||PIAT 612|
|Advanced Pharmaceutical Organic Chemistry||Prerequisites: Pharmaceutical Organic Chemistry
Advanced Pharmaceutical Organic Chemistry is a five credit course offered in the first semester of the first year of the MS pharmaceutical chemistry curriculum. The course goal is to provide the advance knowledge of organic chemistry to graduates who are knowledgeable in the fundamentals of Organic Chemistry. The students will apply this knowledge to course discussion of advancement in organic chemistry by studying catalysis, aromatic nucleophilic reactions, stereochemistry and pericyclic reactions. They will be able to understand and carry out organic synthesis based on above methods. The course also includes advanced organic methods like combinatorial chemistry and its application in synthesis of drug molecules. This promotes use of resources such as library, faculty and information technology. The scheduling of course topics is designed to reinforce topics in other pharmaceutical/medicinal/heterocyclic and natural products and analytical chemistry courses. The following is illustrative of the educational objectives of this course which will be achieved through interactive lecture sessions, self-directed learning (small group sessions, assignments, and seminar and course examinations).
|Theory 3 + Practical 2 = 5||PPOC 613|
|Pharmacokinetics and Pharmacology||Prerequisites: Pharmacology
Pharmacokinetics and Pharmacology is a two credit course offered in the first semester of the first year of the MS curriculum. The course goal is to enrich students’ knowledge regarding the fundamentals of Pharmacokinetics and Pharmacodynamics and provide the ability to relate them to the chemical structure of drugs. The students will apply this knowledge to course discussion of how drugs work, & general principles underlying the interaction of drugs with living systems and drug affinity and efficacy. This will be followed by more detailed discussion of different types of drug–receptor interaction. Students will understand how chemical structure affects the absorption, distribution, metabolism and excretion of drugs. In addition, they will learn the essentials of interpreting pharmacokinetic data for prediction of human doses and therapeutic uses of drugs. This course promotes use of resources such as library, faculty and information technology which leads the students in the development of critical scientific thinking and in the acquisition of appropriate knowledge of pharmacokinetics and pharmacology principles which will help them in their specific area of research. Learning is facilitated through interactive lecture sessions, group discussions, assignments, self-directed learning and problem based learning.
|Theory 2 + Practical 0 = 2||PPAP 614|