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MS in Pharmaceutical Chemistry

Curriculum Summary – MS in Pharmaceutical Chemistry

Year 1

Course Name Course Description No. of Credits Code
Bioorganic Chemistry and Drug Metabolism Prerequisites:Pharmaceutical Organic Chemistry

Bioorganic chemistry and drug metabolism is a three credit course offered in first semester of MS pharmaceutical chemistry. The course focuses on the study of organic chemistry of biological molecules with special emphasis on chemical principles, an extension of basic organic chemistry as applied to the mechanisms by which biologically relevant molecules react and exert their effects.

This course is focusing on drug metabolism or drug biotransformation and enzyme- catalyzed changes in drug structure. Enzymology of drug metabolism reactions including the molecular mechanisms involved. Factors that modulate drug metabolism, and induction and inhibition and external and internal factors are considered in view of the widespread use of poly-pharmacy that the student should not only be aware of potential drug-drug interactions but also be able to rationalize and explain why combination drug therapy interactions occur. The importance of pharmacokinetics in drug action is highlighted. The students gain knowledge in changes in both pharmacological and toxicological responses due to drug biotransformation with an important consideration in drug therapy and pro-drug design. Learning is facilitated through interactive lecture sessions, self-directed learning (assignments, problem based learning, seminar) and course examinations.

Theory 3 + Practical 0 = 3 PBDM 611
Advanced Pharmaceutical Organic Chemistry Prerequisites: Pharmaceutical Analytical Chemistry

The instrumental analytical course is a four credit course offered in the first semester of first year of MS pharmaceutical chemistry curriculum. This course aim to illustrate the theory and practice of quantitative analysis at the advanced level. This course covers the fundamentals of instrumental methods of analysis, emphasizing spectroscopic, chromatographic techniques. This course provides information about the different instrumental techniques employed in qualitative and quantitative determination of drug substances with special reference to quality control and quality assurance. Instrumental/pharmaceutical analysis is vital for successful drug development. It is used to determine a drug’s structure, level of active ingredient and identify contaminants. Pharmaceutical analysts use range of techniques to examine the constituents of various samples throughout the drug development process. These samples include raw materials used in manufacturing and body fluids collected during drug trials. As an analyst the student must be familiar with the principles of modern instrumental analytical techniques, approaches and pharmacology. Regulation demands the work under a strict quality assurance and quality control. Learning is facilitated through interactive lecture sessions, laboratory sessions, self-directed learning (assignments, problem based learning, seminar), laboratory practical experiments and course examinations.

Theory 2 + Practical 2 = 4 PIAT 612
Advanced Pharmaceutical Organic Chemistry Prerequisites: Pharmaceutical Organic Chemistry

Advanced Pharmaceutical Organic Chemistry is a five credit course offered in the first semester of the first year of the MS pharmaceutical chemistry curriculum. The course goal is to provide the advance knowledge of organic chemistry to graduates who are knowledgeable in the fundamentals of Organic Chemistry. The students will apply this knowledge to course discussion of advancement in organic chemistry by studying catalysis, aromatic nucleophilic reactions, stereochemistry and pericyclic reactions. They will be able to understand and carry out organic synthesis based on above methods. The course also includes advanced organic methods like combinatorial chemistry and its application in synthesis of drug molecules. This promotes use of resources such as library, faculty and information technology. The scheduling of course topics is designed to reinforce topics in other pharmaceutical/medicinal/heterocyclic and natural products and analytical chemistry courses. The following is illustrative of the educational objectives of this course which will be achieved through interactive lecture sessions, self-directed learning (small group sessions, assignments, and seminar and course examinations).

Theory 3 + Practical 2 = 5 PPOC 613
Pharmacokinetics and Pharmacology Prerequisites: Pharmacology

Pharmacokinetics and Pharmacology is a two credit course offered in the first semester of the first year of the MS curriculum. The course goal is to enrich students’ knowledge regarding the fundamentals of Pharmacokinetics and Pharmacodynamics and provide the ability to relate them to the chemical structure of drugs. The students will apply this knowledge to course discussion of how drugs work, & general principles underlying the interaction of drugs with living systems and drug affinity and efficacy. This will be followed by more detailed discussion of different types of drug–receptor interaction. Students will understand how chemical structure affects the absorption, distribution, metabolism and excretion of drugs. In addition, they will learn the essentials of interpreting pharmacokinetic data for prediction of human doses and therapeutic uses of drugs. This course promotes use of resources such as library, faculty and information technology which leads the students in the development of critical scientific thinking and in the acquisition of appropriate knowledge of pharmacokinetics and pharmacology principles which will help them in their specific area of research. Learning is facilitated through interactive lecture sessions, group discussions, assignments, self-directed learning and problem based learning.

Theory 2 + Practical 0 = 2 PPAP 614
Course Name Course Description No. of Credits Code
Drug Design and Development Prerequisites:Medicinal Chemistry

Drug design and development is a two credit course offered in the second semester of the first year of the M.S. pharmaceutical chemistry curriculum. The course goal is to provide the foundation of drug development techniques to the graduates. The students will apply this knowledge to course discussion of drug actions, drug receptor interactions and drug design and development methods. They will be able to carry out QSAR and molecular modeling methods. This promotes use of resources such as library, faculty and information technology. The scheduling of course topics is designed to reinforce topics in medicinal chemistry course. Learning is facilitated through interactive lecture sessions, self-directed learning (assignments, problem based learning, seminar) and course examinations.

Theory 2 + Practical 0 = 2 PDDD 621
Heterocyclic chemistry Prerequisites: Pharmaceutical Organic Chemistry

Heterocyclic Chemistry course is a four credit course offered in the second semester of the first year of the MS pharmaceutical chemistry curriculum. The course is aimed to enrich students with advanced knowledge of chemistry of the heterocycles and their therapeutic applications. This course deals with the chemistry of compounds that contain heteroatoms in the ring, their syntheses, reactions and uses in drug production. The heterocycles to be studied include the five and six membered monocycles and the fused heterocycles. Students will understand the importance heterocycles in biological systems and in pharmaceuticals. Students will be able to draw mechanisms for reactions involving heterocycles as starting materials, intermediates and products, and be able to propose syntheses of heterocycles from the major classes. Students will be able to relate significant chemical properties to structure. Learning is facilitated through interactive lecture sessions, self-directed learning (assignments, problem based learning, seminar), laboratory practical experiments and course examinations.

Theory 2 + Practical 2 = 4 PHTC 622
Chemistry of Natural products Prerequisites: Pharmacognosy & Phytochemistry

Chemistry of Natural Products is a four credit course offered in the second semester of the first year of the MS curriculum. The course goal is to provide the foundation for graduates who are knowledgeable with a broad overview of natural product science. The students will apply this knowledge to course discussion of natural products as medicines and general methods associated with the phytochemical investigation of herbal products. They will be able to carry out extraction procedures. This promotes use of resources such as library, faculty and information technology. The scheduling of course topics is designed to reinforce topics in other chemistry course. The following is illustrative of the educational objectives of this course which will be achieved through interactive lecture sessions, self-directed learning (assignments, problem based learning, seminar), laboratory practical experiments and course examinations.

Theory 2 + Practical 2 = 4 PCNP 623
Medicinal Chemistry Prerequisites: Pharmaceutical Organic Chemistry

Medicinal Chemistry is a four credit course offered in the second semester of the first year of the MS pharmaceutical chemistry curriculum. The course goal is to enrich students with advance knowledge of Medicinal Chemistry. The students will apply this knowledge to course discussion of Prodrugs, enzyme inhibitors, recombinant DNA technology, use of microbes in drug preparation, agents affecting immune system and gastric acid secretion inhibitors. They will be able to understand and carry out synthesis of drugs based above various methods. This promotes use of resources such as library, faculty and information technology. The scheduling of course topics is designed to reinforce topics in other pharmaceutical/medicinal chemistry courses. Learning is facilitated through interactive lecture sessions, self-directed learning (assignments, problem based learning, seminar), laboratory practical experiments and course examinations.

Theory 2 + Practical 2 = 4 PMDC 624

Year 2

Course Name Course Description No. of Credits Code
Dissertation and seminar for Pharmaceutical Chemistry Prerequisites:All the courses of previous semester

The dissertation is aimed to train a MS student in research methods and techniques under the guidance of a recognized guide. Student will be trained in literature review, design of research study, data collection, critical analysis, comparison of results, drawing conclusions and making recommendations. The student will have to present two research seminars related to the dissertation topic and progress. The research seminar related to the dissertation work and progress reports given by the students will help in problem solving, team work and leadership qualities. A total of 12 credits is assigned in 3rd and 4th semesters for different areas of dissertation work mentioned. The dissertation submitted will be evaluated by the recognized examiners appointed by the university.

Goals of the MS program research work are to:

    1. Provide advanced training in Pharmaceutical sciences based research work
    2. Offer an opportunity for candidates to advance their knowledge in specific areas of pharmaceutical sciences through research.
    3. Prepare individuals for research and teaching positions needing a strong background in the pharmaceutical sciences.
    4. Develop individuals with the research skills needed to carryout basic and applied studies in pharmaceutical sciences/pharmacy practice.
    5. Prepare graduates to function as independent scholars, who are capable of contributing to the body of knowledge in their areas of specialization through original research.
    6. Address the pharmaceutical and healthcare needs of U.A.E
6 + 6 = 12 PDRS 716 & PDRS 826